Building on MacOS It turns out in order to build Seer for MacOS, you need to set the cmake qt5 environment variable manually. You might want to make a note of it in the build instructions with an example: In order for find_package to be successful, Qt 5 must be found below the CMAKE_PREFIX_PATH, or the Qt5_DIR must be set in the CMake cache to the location of the Qt5Config.cmake file. The easiest way to use CMake is to set the CMAKE_PREFIX_PATH environment variable to the install prefix of Qt 5. Other info: https://stackoverflow.com/questions/18722329/cmake-does-not-find-qt-5-1-1 I successfully built my GUI on MacOSX 10.10 by exporting Linux environment variables $ brew install qt5 $ ls /usr/local/opt/qt5/lib/cmake/Qt5Widgets/Qt5WidgetsConfig.cmake $ /usr/local/opt/qt5/lib/cmake/Qt5Widgets/Qt5WidgetsConfig.cmake $ export CMAKE_PREFIX_PATH=/usr/local/opt/qt5/ $ cd ./build $ cmake ../CMakeLists.txt $ make -j8 So for Seer on MacOS: % cmake -DCMAKE_PREFIX_PATH=/usr/local/opt/qt5/ ..